Survey: Gluten-Free Diet May Improve Symptoms, Behavior Among Autistic Children

(dave pullig/Flickr)

For parents of children with autism, the new findings — that a gluten-free, casein-free diet may help ease kids’ troubling GI symptoms and improve behavior — are nothing new.

Still, the report from Penn State backs what so many of these parents say they’ve experienced: Children appear to get some relief when following a strict diet that eliminates these ubiquitous ingredients (gluten is in most bread and grain products, and casein is found in dairy products).

The study is a survey, which, of course has its limitations. But for parents of children on the autism spectrum, the news suggests that painful physical symptoms associated with the condition might be alleviated through diet.

From the press release:

“Research has shown that children with ASD commonly have GI [gastrointestinal] symptoms,” said Christine Pennesi, medical student at Penn State College of Medicine. “Notably, a greater proportion of our study population reported GI and allergy symptoms than what is seen in the general pediatric population. Some experts have suggested that gluten- and casein-derived peptides cause an immune response in children with ASD, and others have proposed that the peptides could trigger GI symptoms and behavioral problems.”

The team — which included Laura Cousino Klein, associate professor of biobehavioral health and human development and family studies — asked 387 parents or primary caregivers of children with ASD to complete a 90-item online survey about their children’s GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as their children’s degree of adherence to a gluten-free, casein-free diet. The team’s results appeared online this month in the journal Nutritional Neuroscience.

Pennesi and Klein and their team found that a gluten-free, casein-free diet was more effective in improving ASD behaviors, physiological symptoms and social behaviors for those children with GI symptoms and with allergy symptoms compared to those without these symptoms. Specifically, parents noted improved GI symptoms in their children as well as increases in their children’s social behaviors, such as language production, eye contact, engagement, attention span, requesting behavior and social responsiveness, when they strictly followed a gluten-free, casein-free diet.

According to Klein, autism may be more than a neurological disease — it may involve the GI tract and the immune system.

“There are strong connections between the immune system and the brain, which are mediated through multiple physiological symptoms,” Klein said. “A majority of the pain receptors in the body are located in the gut, so by adhering to a gluten-free, casein-free diet, you’re reducing inflammation and discomfort that may alter brain processing, making the body more receptive to ASD therapies.”

The team found that parents who eliminated all gluten and casein from their children’s diets reported that a greater number of their children’s ASD behaviors, physiological symptoms and social behaviors improved after starting the diet compared to children whose parents did not eliminate all gluten and casein. The team also found that parents who implemented the diet for six months or less reported that the diet was less effective in reducing their child’s ASD behaviors.

According to the researchers, some of the parents who filled out the surveys had eliminated only gluten or only casein from their children’s diets, but survey results suggested that parents who completely eliminated both gluten and casein from their child’s diet reported the most benefit.

  • Reasonable?

    This is another good reason to try a Paleo diet even if you don’t have autism.  Whole meats, vegetables fruits and nuts without grains legumes and dairy, decrease the risks of inflammatory diseases and metabolic diseases.  .

    We forget that science is driven by hypotheses that are driven by observations and anecdotes.
    Observatins form scienticially testable hypotheses.  This is one that should be pursued vigorously.  Maybe this simple dietary change can prevent autism if mothers adopt it during pregnancy and nursing….worth a study…right?

  • Anonymous

    Pardon? Where is the actual science to back this up? A survey of parents is about as unscientific as you can get. The real research on special diets for autism shows the opposite of what Pennesi and Klein conclude. http://abcnews.go.com/Health/Autism/gluten-free-casein-free-diet-remedy-autism-study/story?id=10690766#.T06sZ3JWrF8  Can Klein please point us to peer-reviewed research to back up her claim that by “adhering to a gluten-free, casein-free diet, you’re reducing inflammation and discomfort that may alter brain processing, making the body more receptive to ASD therapies”?