Researchers at The Broad Institute and Massachusetts General Hospital found that people with higher genetic levels of the good cholesterol HDL don’t necessarily have more protection or a lower risk of heart disease.
Here’s the Broad’s video explainer.
And the crux of the findings are summarized in this news release:
What they found was surprising. Individuals who carried a particular variation in a gene called endothelial lipase had HDL levels that were elevated about 6mg/dl, or 10% — a change expected to decrease heart attack risk by about 13%. However, these individuals showed no difference in their risk of heart disease compared to people without the variant. Continue reading